It is generally considered that the level of total protein, albumin, globulin, and
fibrinogen in the blood plasma may not deviate from the normal range so that the
functional stability in the course of normal life, especially in subjects of the same
descent, be not disturbed. The gamma globulin among globulin fractions is closely
related to the antibody This globulin is known to increase in cases of such diseases as
acute and chronic infections.
The authors haute determined by the papadopoulos phenol reagent method, the total
protein and the gamma globulin fraction of serum obtained from the tuberculosis
patients, and calculated the ratio of gamma globulin to total protein. We studied and
compared the clinical pictures of these patients with the laboratory data obtained. In
pulmonary tuberculosis it was usually found that the level of total protein in the serum
was normal but the ratio of gamma globulin to total protein increased according to an
increase in the gamma globulin fraction. This may represent one of the significant
differences between normal men and tuberculosis patients.
As a result our observations and determinations, we found that out of the eighty six
patients nine had the low ratio of gamma globulin) to total protein. Out of the nine
cases five(55.6%) showed the Poor improvement upon treatment, the conclusion being
that the patients with the gamma globulin abode normal responded better to
chemotherapy than the patients with) gamma globulin fraction below normal.
In addition, it was also found that with an markedly increased E. S. R. the ratio of
gamma globulin to total protein decreases, and that in Iymphocytosis the ratio was
higher than in Iymphopenia.
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